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Contraindicated (1)pentobarbital decreases levels of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with strong CYP3A4 inducers; these drugs lessen publicity to vandetanib by as much as forty%.pentobarbital will enhance the amount or result of clopidogrel by impacting hepatic/intestinal